ADR reporting systems collect information on adverse health effects caused by both single drugs and DDIs. However, such reactions are typically not observed in clinical drug-development studies because most of them focus on single- drug therapies. The expanded use of multiple drugs has increased the occurrence of adverse drug reactions (ADRs) induced by drug-drug interactions (DDIs). Liu, Ruifeng AbdulHameed, Mohamed Diwan M Kumar, Kamal Yu, Xueping Wallqvist, Anders Reifman, Jaques The World Health Organization-Uppsala Monitoring Centre and Naranjo algorithm causality evaluation afforded similar results.ĭata-driven prediction of adverse drug reactions induced by drug-drug interactions. The World Health Organization-Uppsala Monitoring Centre causality evaluation and Naranjo algorithm results significantly differed from those of the Korean algorithm version II (p contrast media- induced adverse reactions. Causality patterns differed between the two adverse reaction classes. 1.1%, p contrast media- induced adverse reactions (56.6%, p = 0.066). Compared to contrast media- induced adverse reactions, drug-induced adverse reactions were milder, more likely to be preventable (9.8% vs.

Dermatological and gastrointestinal adverse drug reactions were most frequently and similarly reported between drug and contrast media- induced adverse reactions. The most common adverse drug reaction-associated drug classes included nervous system agents and anti-infectives.

The prevalence of spontaneously reported adverse drug reaction-related admissions revealed a suspected adverse drug reaction-reporting rate of 20.9/100,000 (inpatient, 0.021%) and 3.9/100,000 (outpatients, 0.004%). Of 1,335 reports, 636 drug-induced and contrast media- induced adverse reactions were identified. The trends among causality tools measuring drug and contrast- induced adverse reactions were analyzed. Clinical patterns, frequency, causality, severity, Schumock and Thornton's preventability, and type A/B reactions were recorded. Mary's teaching hospital, Daejeon, Korea) from 2010-2012 were classified as drug-induced or contrast media- induced. Adverse drug reactions reported by an in-hospital pharmacovigilance center (St. We analyzed differences between spontaneously reported drug-induced (not including contrast media) and contrast media- induced adverse reactions.

Ryu, JiHyeon Lee, HeeYoung Suh, JinUk Yang, MyungSuk Kang, WonKu Kim, EunYoung Differences between Drug-Induced and Contrast Media- Induced Adverse Reactions Based on Spontaneously Reported Adverse Drug Reactions.

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